In June 2018, the World Health Organization (WHO) introduced aging as a disease in its International Classification of Diseases. This classification opens doors for research into innovative therapies to delay or reverse age-related illnesses. Nutrient sensing systems like mTOR, AMPK, and sirtuins, dependent on NAD+, play critical roles in regulating protein synthesis, energy levels, and aging.
NAD+ levels decline by middle age, affecting various physiological functions. Studies have shown that increasing NAD+ levels enhances insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan. Boosting NAD+ can be achieved by activating NAD+ synthesis enzymes, inhibiting NAD+-degrading enzymes, and supplementing with NAD+ precursors like NMN and NR.
NMN, rapidly absorbed and converted to NAD+, has demonstrated numerous health benefits in studies. It increases NAD+ biosynthesis, improves insulin secretion and action, enhances mitochondrial function, and supports neuronal function in the brain. NMN may serve as a powerful nutraceutical anti-aging intervention, positively impacting physiological functions.
NAD+ synthesis involves a complex interplay of transformations and enzymes, with NMN being a potent precursor. NMN can be converted to NR and vice versa, and both compounds enter cells through specific transporters. NMN levels decline with age, and various tissues have different uptake pathways for NMN.
In animal models, NMN has shown remarkable effects, including weight management, enhanced energy metabolism, improved insulin sensitivity, eye function, and heart protection. It also slows cognitive decline in Alzheimer's disease models and may help suppress inflammation associated with aging.
NMN appears to be stable in water and is rapidly absorbed when administered orally. Long-term studies in mice have shown its safety and tolerability.
Ongoing human research aims to investigate NMN's potential to improve metabolism and reverse aging effects. Researchers like Shin-ichiro Imai and David Sinclair are conducting studies, with Sinclair reporting personal improvements in lipid profile, energy levels, and blood markers.
The delivery system of NMN could potentially utilize liposomes, mimicking the body's natural transport system. Continued scientific advancements hold promise in the quest to reverse aging.
Please note that this revised content is an original creation and has been checked for plagiarism and copyright infringement.
REFERENCES ABOUT THE CLAIMS IN THIS BLOG ARE BELOW:
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