The Decline of NAD+ with Age
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in all living cells, essential for energy metabolism and cellular communication. However, as we age, the levels of NAD+ decline in our bodies, leading to various health issues, including aging and age-related diseases.
NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) are two compounds that have been found to increase NAD+ levels in the body. NMN is a direct precursor to NAD+, while NR is converted to NMN before being converted to NAD+. Both compounds have been shown to increase NAD+ levels in various animal studies, and early human studies suggest that they may be effective in increasing NAD+ levels in humans as well.
Resveratrol is a compound found in red grapes and other fruits, nuts, and plants, and has been shown to activate a protein called SIRT1, which plays a role in regulating cellular metabolism and aging. Studies have suggested that resveratrol may also help increase NAD+ levels by activating a pathway known as the AMPK pathway, which is involved in cellular energy metabolism.
Together, these compounds offer promising potential for maintaining health and delaying the onset of age-related diseases by increasing NAD+ levels in the body. However, further research is needed to fully understand the long-term effects and safety of these compounds, and to determine the most effective doses and delivery methods for optimal results.