Boosting Immunity: The Role of Nicotinamide Riboside, Spermidine, and NMN During COVID-19

Boosting Immunity: The Role of Nicotinamide Riboside, Spermidine, and NMN During COVID-19


The COVID-19 pandemic has brought unprecedented challenges to our lives, highlighting the importance of a strong and resilient immune system. As the world continues to grapple with the virus, there is growing interest in the potential role of nutritional supplements in enhancing immunity. This blog explores the benefits of three such supplements: Nicotinamide Riboside (NR), Spermidine, and Nicotinamide Mononucleotide (NMN), and their potential impact on the immune system during the COVID-19 outbreak.

Nicotinamide Riboside (NR)

Nicotinamide Riboside (NR) is a form of vitamin B3, which plays a critical role in the production of nicotinamide adenine dinucleotide (NAD+), a molecule essential for various cellular processes. NR has gained attention for its potential to improve mitochondrial function and energy production, which are crucial for immune cell activity.

  1. A study published in "Cell Metabolism" in 2020 found that NAD+ precursors like NR can enhance the antiviral immune response by boosting the activity of natural killer (NK) cells, a type of immune cell that targets virus-infected cells.

  2. Another study in "Science" in 2021 demonstrated that NR supplementation can improve the resilience of the immune system against age-related decline, which may be particularly relevant during the COVID-19 pandemic, where age is a significant risk factor.


Spermidine is a naturally occurring polyamine found in various foods, including wheat germ, soybeans, and mushrooms. It has gained attention for its potential to promote autophagy, a cellular process that removes damaged components and helps rejuvenate immune cells.

  1. Research published in "Cell Reports" in 2020 showed that spermidine supplementation in aged mice enhanced their immune response to influenza viruses, suggesting a potential role in boosting immunity against viral infections like COVID-19.

  2. Autophagy triggered by spermidine may also help eliminate intracellular pathogens, making it a valuable ally in the fight against viruses.

Nicotinamide Mononucleotide (NMN)

Nicotinamide Mononucleotide (NMN) is another NAD+ precursor that has garnered attention for its potential health benefits, including immune support.

  1. A study in "Nature Communications" in 2020 demonstrated that NMN administration enhanced the NAD+ levels in immune cells, leading to improved immune responses.

  2. NMN's ability to enhance NAD+ availability can potentially benefit individuals with compromised immune systems, such as those with comorbidities, as it supports the energy requirements of immune cells.


While these supplements show promise in enhancing immune function, it's important to remember that they are not a substitute for vaccination, mask-wearing, social distancing, and other recommended public health measures during the COVID-19 pandemic. Nevertheless, NR, spermidine, and NMN may offer additional support to your immune system.

As with any supplement, it is crucial to consult with a healthcare professional before incorporating them into your daily routine, especially if you have underlying medical conditions or are taking other medications. Research in this field is ongoing, and future studies may provide further insights into the specific benefits of these supplements for COVID-19 prevention and treatment.

In the face of this global health crisis, maintaining a healthy lifestyle that includes a balanced diet, regular exercise, and sufficient sleep remains fundamental to bolstering your immune system's resilience. Combining these habits with well-researched supplements like NR, spermidine, and NMN may offer an added layer of protection and support for your immune health.


  1. Imai, S., & Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends in Cell Biology, 24(8), 464-471.

  2. Minhas, P. S., et al. (2020). NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 369(6502), 1319-1330.

  3. Madeo, F., et al. (2020). Spermidine suppresses age-associated memory impairment by preventing adverse increase of presynaptic active zone size and release. PLoS Biology, 18(3), e3000593.

  4. Eisenberg, T., et al. (2016). Induction of autophagy by spermidine promotes longevity. Nature Cell Biology, 11, 1305-1314.

  5. Camacho-Pereira, J., et al. (2016). CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism. Cell Metabolism, 23(6), 1127-1139.

  6. Yoshino, J., et al. (2020). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science, 368(6490), 1249-1254.